Abstract
microRNAs: The Short Link between Cancer and RT-Induced DNA Damage Response.
Highlights
DNA damage response (DDR) networks have long been noted to be implicated in cell death induced via ionizing radiation [1]
A clear connection has been established between dysfunctional DDR networks and malignancy, clinical trials targeting these pathways in the oncology realm have shown limited efficacy to date [4, 5]
Posttranscriptional regulation of mRNAs mediated by miRs plays a fundamental role in adjusting DDR machinery. miR-421 in neuroblastoma and HeLa cells downregulates ATM kinase, which is a crucial integrator of DNA double-strand break (DSB) repair machinery [19]
Summary
DNA damage response (DDR) networks have long been noted to be implicated in cell death induced via ionizing radiation [1]. These DNA damage sensing and signaling pathways establish control through cell cycle checkpoints, cellular senescence, and apoptosis [2]. New discoveries have unveiled specific roles of proteins in DDR networks, which may serve as potential therapeutic targets and sensitizers to ionizing radiation [3].
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