Abstract
As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B-cell homeostasis, and therefore understanding their participation in B-cell biology could help identify biomarkers and contribute toward curing B-cell-related immune disorders. This review aims to report studies casting light on the roles played by miRNAs in B-cell lineage and function and B-cell-related immune pathologies.
Highlights
MicroRNAs are the most studied class of non-coding RNAs and their gene-expression regulating role is key in various biological and pathological processes
Evidence that miRNAs are needed for B-cell development is given by mice where B-cellspecific deletion of the endoribonuclease Dicer results in a lack of B cells [3]
We describe recent studies shedding light on the roles played by miRNAs in Bcell biology and B-cell-related immune pathologies
Summary
MicroRNAs (miRNAs) are the most studied class of non-coding RNAs and their gene-expression regulating role is key in various biological and pathological processes. MiRNAs play a role in immune processes such as the development of immune cells, inflammation, and tolerance [1, 2]. MiRNAs finely tune the differentiation and activation programs of B cells, influencing their function. B cells are central mediators in humoral immunity and play an important role in transplantation, autoimmunity, and reaction to infectious diseases. It is important to understand in what circumstances miRNAs can influence B-cell function, and immuno-pathology. We describe recent studies shedding light on the roles played by miRNAs in Bcell biology and B-cell-related immune pathologies (major miRNA roles in B cells are reported in Table 1 and Figure 1)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
