Abstract
Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment.
Highlights
The protein products of forkhead box (FOX) constitute an extended family of transcription factors characterized by the presence of an evolutionary conserved “forkhead” or “winged-helix” DNA-binding domain (DBD), a trans-activation or trans-repression effector region.[1, 2]
Findings from recent studies point out that FOX transcription factors might hold the key to significant progress in cancer treatment
FOM1 www.impactjournals.com/oncotarget expression is upregulated in malignancies, but it is barely expressed in non-diving normal cells, as a result indicating specificity for cancer cells in a targeted therapeutic approach [49] [11].Besides, the blooming research on FOX regulation, notably by posttranslational modification proves the importance and complexity of this family in diverse physiological and pathological conditions, including cancer
Summary
The protein products of forkhead box (FOX) constitute an extended family of transcription factors characterized by the presence of an evolutionary conserved “forkhead” or “winged-helix” DNA-binding domain (DBD), a trans-activation or trans-repression effector region.[1, 2]. MiRNAs targeting transcription factors (TFs) have emerged as an important mechanism for gene expression regulation. Tan et al reported that miR-671-5p is a tumor-suppressor miRNA in breast www.impactjournals.com/oncotarget tumorigenesis by directly targeting FOXM1, and demonstrated that overexpression of miR-671-5p in breast cancer cells attenuates cell proliferation and invasion, induces S-phase arrest, inhibits EMT and sensitizes cancer cells to cisplatin, 5-fluorouracil and epirubicin exposure [52].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
