Abstract
MicroRNAs and senescence
Highlights
The discovery and analysis of microRNAs has revealed a new mechanism of gene regulation. miRNAs can base-pair with specific mRNA targets and regulate their expression at the post-transcriptional level [1]
MiR-20a represses the expression of the transcriptional regulator LRF (Leukemia/Lymphoma Related Factor), a repressor of the p19ARF gene
We analyzed the global expression of miRNAs in an established model of cellular senescence in which repression of the human papillomavirus E7 oncogene causes the rapid induction of Rb-dependent senescence in HeLa cervical carcinoma cells [8,9]
Summary
The discovery and analysis of microRNAs (miRNAs) has revealed a new mechanism of gene regulation. miRNAs can base-pair with specific mRNA targets and regulate their expression at the post-transcriptional level [1]. MiR-20a represses the expression of the transcriptional regulator LRF (Leukemia/Lymphoma Related Factor), a repressor of the p19ARF gene. We analyzed the global expression of miRNAs in an established model of cellular senescence in which repression of the human papillomavirus E7 oncogene causes the rapid induction of Rb-dependent senescence in HeLa cervical carcinoma cells [8,9].
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