Abstract
BackgroundBehçet’s disease gives a challenge to be diagnosed and followed up due to lack of specific biomarkers. MicroRNAs showed relations to different disease states including immunological and inflammatory illnesses. In this study, we are estimating microRNA548ac levels for the first time to be tested in the disease to see if there is a link to disease activity and if microRNA548ac can be used as a biomarker for activity or remission and prognosis of Behçet’s disease. MicroRNA548ac has been shown to have a role in autoimmunity and some inflammatory conditions. Blood samples were taken from patients to measure white blood cells expression of microRNA548ac, and compared to its expression in healthy subjects, disease activity was assessed by usage of Behçet’s Disease Current Activity Form (BDCAF).ResultsMicroRNA548ac expression decreased but not significantly with increased Behçet’s disease activity, and expression was having a significant positive correlation with increased treatment response history.ConclusionsMicroRNA548ac appeared not to be related to disease activity which needs confirmation in further studies, but it may predict response to treatment so that patients having higher expression of microRNA548ac may have a better response to treatment. Here, microRNA548ac could be used as a disease biomarker for disease prognosis.
Highlights
Behçet’s disease gives a challenge to be diagnosed and followed up due to lack of specific biomarkers
Our results showed a decrease in miRNA548ac expression in some but not all Behçet’s disease (BD) patients
IFN-λ1 appeared to have a role in Th1 and Th2 cell development and decreases the secretion of Il13 as what was shown in Jordan et al (2007) and Darwish et al (2006) [22, 23], MiRNA548 when tested in Li 2012, it was found that it decreases antiviral response of the host by IFN-λ1 direct targeting [6]
Summary
Behçet’s disease gives a challenge to be diagnosed and followed up due to lack of specific biomarkers. Behçet’s disease (BD) is one of the vasculitides, which is characterized by many systemic manifestations, including oral ulcers, genital ulcers, skin lesions, ocular diseases, neurologic manifestations, rheumatologic complaints (arthralgia ± arthritis), and gastrointestinal disease. These clinical manifestations of BD are due to blood vessel inflammation mainly. MiRNAs play roles in many physiological processes including differentiation, development, proliferation, and apoptosis They appeared to be expression regulators of genes in acquired and innate immune system controlling antibody production and release of Hassouna et al The Egyptian Journal of Internal Medicine (2022) 34:20 inflammatory mediators. Measuring or targeting their expression of might serve as a strategy for diagnosis, prevention, or treatment of various diseases [4]
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