Abstract
Background‘Fine-tuning’ of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricted because only a subset of its target genes is expressed.MethodsHere, we analyze the characteristics of miRNA regulation upon target genes according to tissue-specific gene expression by constructing tissue-specific protein interaction networks for ten main types of tissues in the human body.ResultsCommonly expressed proteins are under more intensive but lower-cost miRNAs control than proteins with the tissue-specific expression. MiRNAs that target more commonly expressed genes usually regulate more tissue-specific genes. This is consistent with the previous finding that tissue-specific proteins tend to be functionally connected with commonly expressed proteins. But to a particular miRNA such a balance is not invariable among different tissues implying diverse tissue regulation modes executed by miRNAs.ConclusionThese results suggest miRNAs that interact with more commonly expressed genes can be expected to play important tissue-specific roles.
Highlights
Implement of complex processes in biology are tremendously dependent on interactions between proteins
Protein interactions are usually mapped into a static protein interaction network (PIN), cautions should be taken that a real PIN is always in dynamic states [4]
PINs and distributed proteins represented as nodes into four categories according to their interaction degree
Summary
Implement of complex processes in biology are tremendously dependent on interactions between proteins. Drafting global human protein interaction map, researchers have the opportunity to explore how proteins fulfill their cellular functions [1,2,3]. Protein interactions are usually mapped into a static protein interaction network (PIN), cautions should be taken that a real PIN is always in dynamic states [4]. Dynamic PIN ensures cell show good robustness when facing various kinds of perturbations from the external environment [5]. An important controllable variable is protein abundance. MicroRNAs (miRNAs) have emerged as vital regulators in ‘fine-tuning’ of protein abundance and are involved in most biological processes [6]
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