Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that function as potent negative regulators of gene expression. They play a critical role in the regulation of genes involved in the cellular and molecular responses to toxicants. Benzo(a)pyrene (BaP) is an environmental contaminant found in cigarette smoke and is one of the polycyclic aromatic hydrocarbons (PAHs). BaP is considered a major contributor of vascular disease. In this study, we investigated whether miRNAs play a role in regulation of various gene expression responses to BaP in human umbilical vein endothelial cells (HUVECs). We performed a pair-wise correlation coefficient analysis on expression levels of 105 miRNAs and 2335 mRNA, and observed anti-correlations between miRNA and mRNA. The Gene Ontology enrichment analysis on the differential expression of miRNA-related genes revealed significant enrichment in the biological processes and signaling pathways. Our results first revealed the expression profiling of miRNAs in endothelial cells and contribute to the improvement of vascular disease.
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