Abstract
Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies.
Highlights
Intraductal papillary mucinous neoplasms (IPMNs) are a class of visceral exocrine mucinous tumors, ranging from benign adenoma to infiltrative carcinoma [1]
We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC)
Recent studies have shown that miRNAs can target important target genes or pathways and play essential roles as oncogenes or tumor suppressor genes in tumorigenesis and progression [21,22,23], miRNA could serve as important cancer diagnostic markers and therapeutic targets
Summary
Intraductal papillary mucinous neoplasms (IPMNs) are a class of visceral exocrine mucinous tumors, ranging from benign adenoma to infiltrative carcinoma [1]. Some miRNAs are highly expressed in tumor tissues and play the roles as oncogenes to promote oncogenesis [7,8,9,10]. Because of their stable nature and the circulating features, miRNAs have been widely used for cancer diagnostics and treatments [11,12,13,14].
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