Abstract
A central question in the field of adult neurogenesis is whether adult-born neurons in the olfactory bulb (OB) become similar to the developmentally generated neurons or if they form cells with unique properties. Although several physiological and morphological differences have been identified, no molecular markers have been found. microRNA (miRNA) are endogenous small non-coding RNA that negatively regulate large networks of mRNA. In a recent study, we have investigated the miRNA activity in OB interneurons. We found miRNA-125 (miR-125) to be specifically absent in developmentally generated OB interneurons, whereas it is highly expressed in the adult-born OB interneurons. Thus, miR-125 can be used as a molecular marker, the first one to our knowledge, to distinguish these cell populations from each other, strengthening that there is divergence between the two populations. This finding reveals novel information regarding adult neurogenesis, temporal differences between OB interneurons as well as it highli...
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