Abstract
Objective: Chemosensitivity is a major determinant of clinical outcome for patients with ovarian cancer (OVCA). However, the molecular basis to chemoresponse remains to be fully characterized. We have previously reported that microRNAs (miRNAs), which influence messenger RNA (mRNA) posttranscriptional control and contribute to human carcinogenesis, may also influence cancer cell response to chemotherapy. In the current study, we sought to identify those miRNAs associated with ovarian cancer cell response to topotecan, gemcitabine and doxorubicin.
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