Abstract
MicroRNAs (miRNAs) are short non-coding RNA molecules that are involved in many physiological and pathological processes. Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells (PCs). Survival of patients is negatively affected by extramedullary disease (EM). EM occurs when PCs migrate out of the bone marrow (BM) and lose the dependence to its microenvironment. The mechanism by which the EM occurs is not yet elucidated. The importance of miRNA in the pathogenesis of MM has been demonstrated by several studies.
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