Abstract
BackgroundColon cancer is a heterogeneous tumor and a leading cause of cancer-related mortality. MicroRNA (miRNA) has been proposed as the biomarker in cancers. The aim of this study was to investigate the clinical significance and potential functional role of miR-937 in colon cancer.MethodsIn the present study, reverse transcription-quantitative polymerase chain reaction (qRT-PCR) was conducted to examine the expression levels of miR-937 in colon cancer tissues and cell lines. Kaplan-Meier curve and Cox regression analyses were used to determine the prognostic impact of miR-937 on survival. Cell Counting Kit-8 and Transwell assays were performed to examine cell proliferation, migration, and invasion, respectively.ResultsmiR-937 was significantly upregulated in colon cancer tissues and cell lines. Clinical analysis results showed that miR-937 expression was associated with lymph node metastasis and TNM stage. Patients with high miR-937 expression predicted a shorter overall survival rate. Functionally, overexpression of miR-937 promoted cell proliferation, migration, and invasion, while inhibition of miR-937 inhibited these cellular behaviors in vitro.ConclusionsThese results suggested that miR-937 may act as a prognostic biomarker and a potential target for therapeutic strategy, as well as promote proliferation, migration, and invasion of colon cancer.
Highlights
Colon cancer is one of the most common malignant tumors of the digestive tract and the leading cause of cancer-related mortality worldwide [1, 2]
Results miR-937 expression levels in colon cancer patients and cell lines The expression levels of miR-937 in tumor and adjacent normal tissue specimens of 109 colon cancer patients were detected by the reverse transcriptionquantitative polymerase chain reaction (qRT-PCR) assay
The expression levels of miR-937 were determined in colon cancer cell lines (LoVo, SW620, CW-2, HCT116) and a normal colonic epithelial cell line NCM460
Summary
Colon cancer is one of the most common malignant tumors of the digestive tract and the leading cause of cancer-related mortality worldwide [1, 2]. Colon cancer patients at early stages often have longterm survival, colon cancer with early-onset symptoms is not typical and the patients usually initially diagnosed at advanced stages with unsatisfactory prognosis [4]. Better cancer-related biomarkers and Numerous studies have demonstrated that abnormal expression of microRNAs (miRNAs) is closely linked to the initiation and development of cancers [6]. MiRNAs, including miR-378 [11], miR-590-3p [12], and miR-34b [13], are abnormally expressed and function as oncogenic or suppressor role in colon cancer. Colon cancer is a heterogeneous tumor and a leading cause of cancer-related mortality. The aim of this study was to investigate the clinical significance and potential functional role of miR-937 in colon cancer
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