Abstract
MicroRNA-199a (miR-199a) inhibits the progression of several hematological malignancies and enhances the sensitivity to chemotherapy in acute myeloid leukemia (AML), but its clinical role in AML needs further investigation. This study aimed to explore the correlation of miR-199a with clinical features and prognosis in pediatric AML patients. Totally, 71 pediatric AML patients were enrolled. Their bone marrows (BMs) before and after one course of treatment were collected. Besides, 30 pediatric patients with nonmalignant hematological disease who underwent BM examination were enrolled with their BMs collected. miR-199a expression was detected by reverse transcription-quantitative polymerase chain reaction. miR-199a expression was lower in pediatric AML patients than in controls (p < 0.001). Meanwhile, downregulated miR-199a expression was correlated with the occurrence of FLT3-ITD mutation (p = 0.023), higher BM blasts (p = 0.037), poor NCCN risk stratification (p = 0.012) and unfavorable Chinese Medical Association risk stratification (p = 0.002) but not associated with other clinical features. Additionally, downregulated miR-199a expression was correlated with lower complete response (CR) rate after one course of treatment (p = 0.036). Interestingly, after treatment, miR-199a expression was increased in patients who achieved CR (p < 0.001), but remained unchanged in those who didn’t achieve CR (p = 0.163). Moreover, downregulated miR-199a expression was correlated with shorter event-free survival (p = 0.021); meanwhile, it showed a trend of associating with poor OS (p = 0.055), which was not statistically significant. In this series, decreased expression of miR199a was associated with inadequate treatment response and worse OS in pediatric AML patients, indicating its potential as a prognostic biomarker for pediatric AML. Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.2022045
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