Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that serve an important function in carcinogenesis and tumor progression. The present study investigated the roles and mechanisms of miRNA-125b (miR-125b) in human hepatocellular carcinoma (HCC). miR-125b was significantly downregulated in the examined HCC tissues and cell lines. Overexpression of miR-125b reduced HCC cell migration and invasion. By contrast, inhibition of miR-125b expression significantly accelerated HCC cell migration and invasion. In addition, the present study identified transcriptional coactivator with PDZ-binding motif (TAZ) as a functional downstream target of miR-125b. Furthermore, overexpression of TAZ impaired miR-125b-induced inhibition of invasion in HCC cells. The current study demonstrated that miR-125b may be involved in the tumorigenesis of HCC at least in part by the suppression of TAZ.
Highlights
Hepatocellular carcinoma (HCC) is the sixth most prevalent type of cancer worldwide and the fourth most common cause of cancer‐associated mortality [1,2]
In order to study the expression of miR‐125b and its significance in HCC carcinogenesis, expression levels of miR‐125b were measured in 20 pairs of HCC tissue samples and their corresponding control liver tissues using reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR)
The results indicated that miR‐125b expression was significantly reduced in HCC tissues compared with the normal tissues (P
Summary
Hepatocellular carcinoma (HCC) is the sixth most prevalent type of cancer worldwide and the fourth most common cause of cancer‐associated mortality [1,2]. Uncontrolled tumor metastasis, frequent intrahepatic spread and extrahepatic metastasis are the primary causes for the poor prognosis in HCC [6]. Improved understanding of the molecular mechanisms that underlie. HCC invasion and metastasis is essential for the development of novel therapeutic strategies. Previous evidence has indicated that the dysregulation of miRNAs may lead to alterations in diverse biological processes, including proliferation, differentiation and apoptosis, which are associated with the development of cancer [7,8]. Several dysregulated miRNAs, including miR‐221, miR‐21, miR‐452, miR‐424 and miR‐125b, have been demonstrated to regulate HCC cell growth, apoptosis, migration and/or invasion [9,10,11,12,13]. The role and the underlying molecular mechanisms of miR‐125b in HCC remain largely unknown
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