Abstract
MicroRNAs (miRNAs) are noncoding single‐stranded RNAs, approximately 20‐24 nucleotides in length, known as powerful posttranscriptional regulators. miRNAs play important regulatory roles in cellular processes by changing messenger RNA expression and are widely involved in human diseases, including tumors. It has been reported in the literature that miRNAs have a precise role in cell proliferation, programmed cell death, differentiation, and expression of coding genes. MicroRNA‐124 (miR‐124) has reduced exparession in various human neoplasms and is believed to be related to the occurrence, development, and prognosis of malignant tumors. In our review, we focus on the specific molecular functions of miR‐124 and the downstream gene targets in major cancers, which provide preclinical evidence for the treatment of human cancer. Although some obstacles exist, miR‐124 is still attracting intensive research focus as a promising and effective anticancer weapon.
Highlights
INTRODUCTION TOMIR‐124In 2002, miR‐124 was first discovered in mice.[4]
Li et al suggested that lncRNA 1308 may function as a competing endogenous RNA for miR‐124 to regulate lung cancer cell invasion through the miR‐124/ADAM 15 signaling pathway, indicating that lncRNA 1308 and miR‐124 both have important roles in the disease progression of nonsmall cell lung cancer (NSCLC).[105]
Xiao et al found that miR‐124 was significantly decreased in nasopharyngeal carcinoma (NPC) and that a miR‐124 mimic could inhibit NPC cell (CNE1 and CNE2) proliferation, migration, and invasion via binding with the target gene forkhead box Q1 (Foxq1).[107]
Summary
INTRODUCTION TOMIR‐124In 2002, miR‐124 was first discovered in mice.[4]. Subsequent research showed that miR‐124 is highly conserved and has been found to be expressed in both simple nematodes and complex humans.
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