Abstract
MicroRNAs (miRNAs) are short non-coding RNA molecules that play a significant role in many types of cancers including breast cancer. In the current study, we evaluated the expression levels of microR-10b (miR-10b) in 115 breast cancer patients from Sichuan Cancer Center. Real time reverse transcription-PCR was used to assess miR-10b expression. Clinical data including disease stage, survival status, age, ER/PR/HER2 status, molecular subtypes, tumor size, lymph node status and Ki-67 expression levels were correlated with miR-10b expression levels. Our data showed that the miR-10b expression is correlated with disease stage, living status and tumor sizes. We also found that miR-10b expression levels are higher in the lymph node positive group and the Ki-67 higher scoring group (score > 20). No statistically significant differences were observed based on age or molecular sub-type grouping. In conclusion, miR-10b may be a biomarker for breast cancer and is a potential treatment target.
Highlights
Breast cancer is the second most common cancer diagnosed worldwide with an estimated 249,260 new cases, and 40,890 deaths, estimated to occur in the United States during 2016 [1]
One slide was chosen for H&E and four slides were chosen for immunohistochemical analysis for Ki-67, estrogen receptor (ER), progesterone receptor (PR), and HER2
MiR-10b expression levels correlate with malignant status in human breast cancer
Summary
Breast cancer is the second most common cancer diagnosed worldwide with an estimated 249,260 new cases, and 40,890 deaths, estimated to occur in the United States during 2016 [1]. This makes breast cancer the second leading cancer type for estimated new cancer cases and deaths for 2016 [1]. In China, breast cancer is the second most common malignancy and the fourth leading cause of cancer-related death among females [1, 2]. In the past two decades, China has experienced an alarming increasing incidence of breast cancer [2]. Due to the heterogeneity of breast cancer, a significant number of patients will succumb to regional or distant metastases
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