Abstract
The dynamics of microtubule is characterized by treadmill-like motion, which is a result of polymerization and depolymerization processes. Such non-equilibrium motion of the microtubule can be suppressed by adding paclitaxel. Thus, the paclitaxel stabilized microtubule is regards as an equilibrium system. In this study, we investigate an effect of the non-equilibrium treadmill-like motion on the viscoelasticity. In the particle tracking experiments, the mean squared displacement (MSD) of microbeads in non-equilibrium microtubule system is larger than that of equilibrium system with paclitaxel. Effect of the paclitaxel on the diffusivity of microbeads corresponds to the result of the dynamics viscoelasticity, where the storage modulus of the equilibrium system is larger than that of non-equilibrium system. In the presence of the paclitaxel, the variance of MSD is also larger compared to the non-equilibrium system. These results indicate that equilibrium microtubule system forms inhomogeneous microtubule network structure, while non-equilibrium microtubule system has relatively homogeneous network. We will also present experimental results of confocal rheometry.
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