Microproteinuria Predicts Organ Failure in Patients Presenting with Acute Pancreatitis.

Abstract

The disease course of acute pancreatitis (AP) ranges from mild and self-limiting to severe inflammation, associated with significant morbidity and mortality. At present, there are no universally accepted and reliable predictors for severity. Microproteinuria has been associated with the presence of systemic inflammatory response syndrome as well as trauma, although its association with AP is not well understood. The aim of this study was to investigate the value of microproteinuria to predict development of organ failure in AP. Consecutive AP patients were prospectively enrolled. Urine samples were collected upon admission, 12-24h after admission, and 3months post-discharge for calculation of urine α1-microglobulin-, albumin-, IgG-, and IgM/creatinine ratios. Data regarding AP etiology, severity, and development of organ failure were registered. Overall, 92 AP patients were included (14% with organ failure; 6% with severe AP). The α1-microglobulin-, albumin-, and IgG/creatinine ratios correlated with high-sensitivity C-reactive protein 48h after admission (r=0.47-0.61, p<0.001 for all). They were also significantly higher in patients with versus without organ failure (p<0.05 for all). The α1-microglobulin/creatinine ratio upon admission predicted organ failure [adjusted odds ratio 1.286, 95% confidence interval (CI) 1.024-1.614] with similar accuracy (AUROC 0.81, 95% CI 0.69-0.94) as the more complex APACHE II score (AUROC 0.86, 95% CI 0.70-1.00). The α1-microglobulin/creatinine ratio upon presentation with AP is related to inflammation and predicts development of organ failure. Further studies are warranted to evaluate its potential usefulness in predicting outcome for AP patients.