Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases.

Yao Wan,Lin Wang,Wenzhou Xu,Xuan Ren,Yu Wang,Wenzhou Xu,Biao Dong,Biao Dong

doi:10.3389/fbioe.2020.00628

Abstract

Nowadays, the heavy burden of oral diseases such as dental caries, periodontitis, endodontic infections, etc., and their consequences on the patients’ quality of life indicate a strong need for developing effective therapies. Bacterial infections played an important role in the field of oral diseases, in-depth insight of such oral diseases have given rise to the demand for antibacterial therapeutic strategies. Recently, microporous frameworks have attracted tremendous interest in antibacterial application due to their well-defined porous structures for drug delivery. In addition, intensive efforts have been made to enhance the antibacterial performance of microporous frameworks, such as ion doping, photosensitizer incorporation as building blocks, and surface modifications. This review article aims on the major recent developments of microporous frameworks for antibacterial applications against oral diseases. The first part of this paper puts concentration on the cutting-edge researches on the versatile antibacterial strategies of microporous materials via drug delivery, inherent activity, and structural modification. The second part discusses the antibacterial applications of microporous frameworks against oral diseases. The applications of microporous frameworks not only have promising therapeutic potential to inhibit bacterial plaque-initiated oral infectious diseases, but also have a wide applicability to other biomedical applications.

Highlights

Oral diseases such as caries, periodontitis, and endodontic infections, attracted tremendous attentions all over the world since such diseases account for a vast burden of morbidity and healthcare spending
It could be concluded that, after 28 days of treatment with water or saliva, there was no significant difference in the bactericidal efficacy of silver-zeolite doped tissue conditioner against C. albicans
It is considered that most of these microporous frameworks and their nanocomposites are uncommercialized and their acquisition procedures are complex, which limits their wide range of clinical applications

Summary

Introduction

Oral diseases such as caries, periodontitis, and endodontic infections, attracted tremendous attentions all over the world since such diseases account for a vast burden of morbidity and healthcare spending. An authoritative report claimed that dental caries and periodontitis were the first and 11th most prevalent causes of disease worldwide in 2016 (Vos et al, 2017), which was 5.4 million as a result of severe periodontitis, 4.6 million as a result of untreated caries in permanent teeth (Papapanou and Susin, 2017). The estimated costs of totaling worldwide in dental infectious diseases amounted to more than $540 billion dollars in 2015 (Righolt et al, 2018). Microporous Materials Against Oral Diseases diseases were closely related with pulmonary disease (Manger et al, 2017), cardiovascular disease (Sanz et al, 2020), and gastrointestinal cancer (Chen et al, 2019). Antibiotics are usually applied as major or auxiliary approach in treatment of such oral infectious diseases. The inferior biocompatibility, short half-time period, and unexpected cytotoxicity limit the potential applications for these materials

Objectives

Findings

Conclusion