Abstract
Surface enhance Raman scattering (SERS) is emerging as a powerful technology for the label-free detection of various biological and chemical species. One of the important but often overlooked considerations in the design of surface-enhanced Raman scattering (SERS) substrates for trace detection is the efficiency of sample collection. Conventional designs based on rigid substrates such as silicon, alumina, and glass resist conformal contact with the surface under investigation, making the sample collection inefficient.The aim of our work is to develop an effective paper-based test strip to achieve high SERS performance for biosensing. Here we present one-step green-fabrication of bimetallic nanoparticles Au/Ag (3D porous stricture) loaded on filter paper using microplasma system. This approach requires a minimal fabrication effort and cost, also contains nanoisland and nanogaps (<20nm) on paper substrate to generate a high density of hot spot(~2000/um2). The 3D biomimetric substrate shows a low detection limit for Rhodamine 6G, high averaged enhancement factor, excellent signal uniformity, good stability and suitability in biosensing. In addition, the novel substrate was applied in label-free folic acid, dopamine and other Raman probe detection with small amount and low concentration of analyte, and it exhibited effective SERS platform potential for bio-detection and bio-sensing. Figure 1
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