Year-end Sale % OFF 
Abstract
Microparticles based on segmented polyurethane were synthesized by polycondensation of a series of diols having various molecular weight with tolyene-2,4-diisocyanate in water-in-oil emulsion. The resulting spherical microparticles were 6-10 μm in diameter following the Gauss distribution. The size of microcapsules at maximum distribution band increases with growing PEG length. It was observed that with higher length of PEG wall surfaces of capsules become more stable mechanically, however a capsule itself is no more brittle and rough. Some aggregation also occurs for microparticles based on PEG 4200. Since respiratory way of drug administration considers size of particles within 1-10 μm as the most applicable, the resulting PU microparticles could be an ideal candidate as domain for respirable antiTB drug administration.
Highlights
At present there is an increased interest in the preparation and characterization of microparticles prepared by interfacial polycondensation because microencapsulation gives numerous advantages and benefits for application [1,2]
It is quite important to note that the size of polyurethane microcapsules and their distribution are extremely important for their application for targeted delivery by respiratory way
During the second step the forpolymer reacts with water or diols to condense in a linear macromolecular chain: In a water-in-oil (W/O) system, an aqueous droplet suspension containing one monomer is formed in an immiscible solvent containing a complementary monomer in the presence of a suitable stabilizer
Summary
At present there is an increased interest in the preparation and characterization of microparticles prepared by interfacial polycondensation because microencapsulation gives numerous advantages and benefits for application [1,2]. Polyurethane microparticles may be produced by two chemical procedures: by polycondensation of a diamine with bischloroformates or by reaction between a diol and a diisocyanate [5]. Our main purposes were to modify the way of synthesis as well as to determine the best chemical components for obtaining the capsules with satisfactory size distribution and good mechanical properties.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
