Microparticles in the air of industrial cities as a risk factor of bronchial asthma

Abstract

Introduction. Suspended particles in ambient air of cities increase the risk of developing respiratory and cardiovascular diseases. At the same time, data on the role of suspended particles in the formation and complication of the course of bronchial asthma (BA) are extremely limited. The aim of study was to substantiate the design of a study to study the effect of fine suspended particles in atmospheric air on the development of the T2 endotype of BA. The design of a "case-control" study was developed and implemented, including patients with the T2-endotype of BA and persons in the control group. In order to verify the diagnosis of BA, General clinical methods of examination and specific allergological examination are used. In parallel, the quantitative characteristics and qualitative composition of suspended particles in atmospheric air are studied with the determination of the mass of suspended particles, dispersion, chemical and microbiological (muldi-tof mass spectrometry, PCR analysis) composition. Atmospheric air samples will be collected using a cascade impactor in the area where patients with bronchial asthma and control groups live. For each fraction, the following will be analyzed: suspended particle mass, dispersion, chemical and microbiological (muldi-tof mass spectrometry, PCR analysis) composition. Conclusions. The study will assess the risk of T2-endotype formation of bronchial asthma with various quantitative and qualitative characteristics of suspended microparticles in the atmospheric air.