Abstract
The microparticles of poly(lactic-co-glycolic acid) (PLGA) and poly(methyl methacrylate) (PMMA), and microcapsules of ibuprofen-PLGA, ibuprofen-polylactic acid (PLA), and ibuprofen-PMMA were successfully prepared using the solvent extraction of oil-in-deep eutectic solvent (O/DES) emulsions with dichloromethane (DCM) or ethyl acetate (EA) as solvent of the oil phase, [ChCl] [DL-malic acid] or [ChCl] [malonic acid] as DES, and water, 1 wt% PVA solution in water, or ethanol as antisolvent. The morphology of the product microparticles and microcapsules were characterized by the SEM and found to be dependent on the solvent of the oil phase in the O/DES emulsions rather other the surfactant, which was essentially the outcome of interplay between polymer solution phase separation with polymer chain mobility. The encapsulation efficiencies (EEs) and drug loading efficiencies (DLEs) of the microcapsules were determined experimentally in the ranges of 14.5-16.4% and 87.1-98.9%, respectively. The In-Vitro test conf...
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