Abstract
Our aim wa s to investigate the adverse effects of occupational exposure to trivalent chromium in tannery workers and unexposed persons. Trivalent chromium used in tanning industry is an environmental contaminant that acts as a carcinogen towards humans and animals. The carcinogenic potential of metals is a major issue in defining human health risk from exposure. In the present investigation, 84 tannery workers and 52 control subjects with similar mean ages, smoking prevalences and alcohol consumption were enrolled for DNA damage analysis in buccal cells by Micronucleus assay (MN). Workers showed a significant increase in micronucleated cells when compared to controls with respect to their smoking habits, alcohol consumption, age and years of exposure. The current study suggests that chronic occupational exposure to Chromium during tanning could lead to increased levels of DNA damage. The res ults of the present investigation are in agreement with those obtained with the same Cr (III) compounds in mutagenicity assays in bacteria and carcinogenicity tests in rodents. A re-evaluation of the mechanisms of chromium carcinogenisis is proposed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Bioscience, Biochemistry and Bioinformatics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
