Abstract
Objective: To compare chromosomal damage in lymphocytes of individuals who did or did not report first-degree relatives with cancer.Materials and methods: Cases and controls (68 each) were matched for sex, age and radon exposure. Chromosomal damage was quantified as frequency of micronucleus-containing cells and proportion of centromere-free micronuclei.Results: Individuals not reporting cancer in their families showed lower values of both the frequency of micronucleus-containing cells (n.s.) and the proportion of centromere-free micronuclei (p < 0.05) in some subgroups, but not in all.Conclusion: The chromosomal damage observed may be due to inheritable genomic instability, but environmental influences cannot be excluded.
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