Micronization of Curcuma xanthorrhiza Extract with Addition of PVP Using Supercritical CO2 as Anti-solvent

Rucita Ramadhana,Motonobu Goto,Sugeng Winardi,Wahyudiono Wahyudiono,Syahna Almadilla,Sarah Duta Lestari,Siti Machmudah,Rizky Prasetya,M Shimada

doi:10.1051/matecconf/202133308002

Rucita Ramadhana, Motonobu Goto + Show 7 more

Open Access

https://doi.org/10.1051/matecconf/202133308002

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Abstract

Curcuma xanthorrhiza Roxb, known as Temulawak or Javanese ginger, is a plant species. Its rhizomes are used as a medicinal herb. It contains curcumin as an active compound and ethereal oils mainly consisted of sesquiterpenes. In this work, Curcuma xanthorrhiza Roxb ethanolic extract was micronized with an addition of PVP using supercritical antisolvent (SAS) method. The ethanolic extract was obtained from dried Curcuma xanthorrhiza Roxb using soxhletation. For the micronization, the extracted compound solvent was a mixture of acetone and ethanol (90:10 (v/v)), while the supercritical CO2 was used as an antisolvent. The effect of operating conditions on the particle size and morphology was evaluated. Through this method, spherical Curcuma xanthorrhiza/PVP particles with mean diameter ranging from 191 ± 70 nm to 178 ± 57 nm were successfully formed. The particle size not significantly decreased as the pressure increased from 8 12 MPa. The addition of PVP is very effective to reduce the particle size, increase the solubility, and enhance the bioavailability of Curcuma xanthorrhiza extract. This work has the potential to improve the use of Curcuma xanthorrhiza in pharmaceutical and nutraceutical applications.

Highlights

For several years an increasing number of herbal medicines has appeared in worldwide marketplace
Based on the P-T diagram reported by Ziegler et al (1995), it can conclude that the operating condition in this study were conducted in the mixture critical point (MCP)
The variety in operating pressure induced an insignificant effect on the morphology and the particle size distribution

Summary

Introduction

For several years an increasing number of herbal medicines has appeared in worldwide marketplace. There are many varieties of plant that can be studied in deliver its function for herbal medicine. Natural products are known as more drug-likely and biological friendly than synthetic molecule product. Many of them have been proven to have better compatibility with biological system and lesser side effect (Oon et al, 2015). The studies for modern pharmaceutical industry has been more focused on medicine from natural product. One of the most known used on plant-based-medication is the Curcuma genus, which consist of more than eighty species. Curcuma xanthorrhiza Roxb, known as Temulawak or Javanese ginger, is an original plant from Indonesia that belongs to Zingiberaceae family. The cultivation of this plant is grown wild in Thailand, Indochina, The Malay Archipelago, India, Japan, Korea, and Northern Australia (Jantan et al, 2012)

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