Abstract
The ultra-fine particles of antibiotic aztreonam have been successfully prepared via a supercritical anti-solvent (SAS) process, by using the mixtures of dimethyl sulfoxide (DMSO) and ethanol as solvents and carbon dioxide as an anti-solvent. A series of precipitation experiments was conducted at different pressures, temperatures, and concentrations of the mixed solvents to explore the influence of these process parameters on the characteristics of the resultant particles. The experimental results reveal that submicron aztreonam particles with narrow size distribution were generated in supercritical region, while expanded micro-spheroids were formed in superheated vapor region.
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