Microneedles: An advanced approach for transdermal delivery of biologics

Abstract

Nowadays, biotherapeutics are playing an essential job in the treatment of an assortment of diseases such as cancer, infectious diseases and etc. Be that as it may, the inherent properties of therapeutic proteins stay a noteworthy obstruction for transdermal delivery, including their moderately huge molecule size and susceptibility to degradation. These issues of biotherapeutics can be overwhelmed by utilizing microneedles (MNs), which are prepared to do easily navigating the horny layer and legitimately moving protein drugs into the systematic circulation. MNs are intended to incorporate appropriate structural materials yet as therapeutics or formulations with tailored physicochemical properties. This platform has been applied to convey drugs both locally and systemically in applications beginning from vaccination to diabetes and cancer therapy. The present review focuses on importance of MN technology in transdermal delivery of biologics, mechanism of transdermal delivery of drugs through MNs, different materials used for the fabrication of MNs, potential challenges associated with transdermal delivery of different biologics through MNs. Moreover, improved performance of biologics delivered through the MNs and biologics MNs in clinical trials is also summarized. Thus, MNs as promising tool which displayed profound guarantee for biomedical applications.