Abstract

Microneedle-mediated transdermal transport of selected triptans: frovatriptan succinate monohydrate and rizatriptan benzoate

Highlights

  • Migraine is a common neurological disorder which is characterized by recurring pulsatile pain on one or both sides of the head [1]

  • The episodic disorder is a significant socioeconomic problem because migraine attacks are ranked sixth in the cause of years of life lost in individuals due to physical or mental impairment in the universal population and rank third for years of life lost in individuals

  • A solid, stainless-steel microneedle roller was used in this study to deliver antimigraine agents Frovatriptan succinate monohydrate (FSM) and Rizatriptan benzoate (RB) across pig ear skin (Figure 1)

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Summary

Introduction

Migraine is a common neurological disorder which is characterized by recurring pulsatile pain on one or both sides of the head [1]. The episodic disorder is a significant socioeconomic problem because migraine attacks are ranked sixth in the cause of years of life lost in individuals due to physical or mental impairment in the universal population and rank third for years of life lost in individuals

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