MICROMORPHOLOGICAL PECULIARITIES OF RELATIONSHIPS IN THE “PARASIT-HOST” SYSTEM

Abstract

Micromorphological, histochemical and pathomorphological features of relationships in the “parasite-host” system before and after exposure to the antitremum (at a dose of 200 mg / kg of LW) and tegalide (at a dose of 30 mg / kg of LW) were studied in a comparative aspect using the example of parasitizing by a Paramphistomum cervi in sheep intestines. The effect of anthelmintics on trematodes is associated with endostation of the parasite, in which certain trophic links are formed between the host and the helminth. The adhesion in the morphofunctional complex “tegument-epithelial tissue of the intestinal villus” at paramphystomy of sheep is considered as an indicator of the maturity of the reciprocal relationship between the parasite and the host. Pathomorphological changes in the mucous membrane of the intestine of sheep with paramphystomy are characterized by the presence of proliferation, hyperplasia and metaplasia, which provide the dynamic stability of the parasite-host system in the endostation of the parasite. Pathomorphological manifestations in the small intestine of sheep with paramphystomy and chemotherapy with tehalide and antithyroid consist of alternative dystrophic and proliferative processes. With the introduction of anthelmintic into the host organism, a violation of the homeokinetic state of each of the biological species that make up this binary system occurs, which leads to destabilization and homeoclase, and then to the death of the system and the development of the disease with clinical manifestations.The micromorphological features of interrelations in the “parasite-host” system, studied with the example of parasitic Paramphistomum cervi in the intestine of spontaneously-infested sheep, before and after the anthelmintic effects of antitermite and tehalid reveal the mechanisms of morphofunctional interrelations in the process of transition of the “parasite-host” from the homeoresistive state to the homeoclasis one and allow you to assess the impact efficiency of anthelmintics with trematodoses.