Micromechanics-Based Modeling of Biological Tissues Using the High-Fidelity Generalized Method of Cells

Abstract

ABSTRACTThe fundamental problem of micromechanics is the prediction of overall response of a composite material given the properties or response of the individual constituents and their internal geometric arrangement. The recently developed High-Fidelity Generalized Method of Cells is a promising micromechanics model whose predictive capability has been demonstrated for infinitesimal deformations in the presence of inelastic constituent behavior. The extension of this micromechanics model to the finite-deformation regime and incorporation of the quasi-linear viscoelasticity theory for the constituent response extends the range of this model's applicability to the bio-engineering area. Herein, an application involving the response of mitral valve chordae tendineae is presented that demonstrates the model's capability to mimic experimentally-observed response of this class of biological tissues rooted in their characteristic microstructures.