Micromachinng chemical and biochemical analysis and reaction systems on glass substrates

Abstract

Microfluidic systems micromachined in glass chips serve as systems for chemical analysis or sensing. Using electroosmotic pumping, applied voltages control the direction of fluid flow without the need for valves. Mixing of reagent solutions, chemical reactions and separation of compounds in mixtures can be achieved. Demonstration of pre-separation mixing of chemical reagents for reaction on-chip, post-separation fluorescent labelling on-chip, and immunological assays on-chip is presented.