Abstract
Antiserum to arginine 8-vasopressin was microinjected bilaterally into the dentate gyrus of the dorsal hippocampus and the effect on passive avoidance behavior was studied. After the single learning trial of a passive avoidance response, immediate bilateral injection of 1 μl antiserum (diluted to 1 50 ) attenuated passive avoidance responding 24 hr later. In immunocytochemical control studies with injection of undiluted antiserum into the dentate gyrus a spreading was observed towards the ventral hippocampus and the dorsal septum. Additionally, administration into the lateral ventricle of 2 μl of 1 50 dilution of the antiserum did not affect the behavior. For an attenuation of passive avoidance behavior via intraventricular injection, 2 μl of a 1 10 dilution of anti-AVP was required. These data suggest that endogenous vasopressin in the septo-hippocampal system might be involved in memory processes.
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