Abstract
In recent years, improving data have shown that under different pathological conditions, microglia can be either supportive for neurogenesis and homeostasis or even detrimental for neural repair. Even if the factors leading microglia to assume its different phenotypes are still unknown, it is tempting to speculate that its heterogeneity may reflect the variety of roles that microglia plays physiologically. According with very recent data, microglia develops from a specific precursor within the yolk sac and once reached the brain give rise to a self-renewal population independent from the monocyte-macrophage lineage.
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