Abstract
Intracerebral hemorrhage (ICH) features extremely high rates of morbidity and mortality, with no specific and effective therapy. And local inflammation caused by the over-activated immune cells seriously damages the recovery of neurological function after ICH. Fortunately, immune intervention to microglia has provided new methods and ideas for ICH treatment. Microglia, as the resident immune cells in the brain, play vital roles in both tissue damage and repair processes after ICH. The perihematomal activated microglia not only arouse acute inflammatory responses, oxidative stress, excitotoxicity, and cytotoxicity to cause neuron death, but also show another phenotype that inhibit inflammation, clear hematoma and promote tissue regeneration. The proportion of microglia phenotypes determines the progression of brain tissue damage or repair after ICH. Therefore, microglia may be a promising and imperative therapeutic target for ICH. In this review, we discuss the dual functions of microglia in the brain after an ICH from immunological perspective, elaborate on the activation mechanism of perihematomal microglia, and summarize related therapeutic drugs researches.
Highlights
Intracerebral hemorrhage (ICH) has become one of the most common and lethal diseases in the last decades (Zhou M. et al, 2019)
We describe the dualistic roles of microglia in ICH from an immunological perspective, expound on the detailed mechanism of perihematomal microglial activation and polarization, and summarize the related therapeutic researches
Since no reliable clinical benefits are provided from surgical hematoma removal at present, promoting hematoma devouring by microglia is of great significance
Summary
Local inflammation caused by the over-activated immune cells seriously damages the recovery of neurological function after ICH. As the resident immune cells in the brain, play vital roles in both tissue damage and repair processes after ICH. The perihematomal activated microglia arouse acute inflammatory responses, oxidative stress, excitotoxicity, and cytotoxicity to cause neuron death, and show another phenotype that inhibit inflammation, clear hematoma and promote tissue regeneration. The proportion of microglia phenotypes determines the progression of brain tissue damage or repair after ICH. Microglia may be a promising and imperative therapeutic target for ICH. We discuss the dual functions of microglia in the brain after an ICH from immunological perspective, elaborate on the activation mechanism of perihematomal microglia, and summarize related therapeutic drugs researches
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
