Abstract
Parkinson’s disease (PD) is an age-related neurodegenerative disease, and its main pathological feature is the specific reduction of dopamine neurons in the substantia nigra of the midbrain and α-synuclein aggregates. However, the specific molecular mechanism of the degeneration of dopamine neurons in the substantia nigra is still not fully understood. Neuroinflammation is involved in the development of PD, and microglia-mediated neuroinflammation plays an important role in the degeneration of dopamine neurons. This article will review the mechanism of microglia-mediated neuroinflammation in the pathological process of PD, and provide new understanding for the molecular mechanism and treatment of PD.
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