Microfluidics of Nanodrug Delivery at Different Angles of Drug Injection

Abstract

Studies into methods of using microelectromechanical systems (MEMS) technology for medical and biological application have led to the development of several interesting devices such as microneedles, micropumps, and microreservoirs. Such microsystems featuring controlled transport process are important in laboratory testing of predecessors of implantable smart devices as well as analysis of pharmaceuticals and performing biomedical precision tasks. In the present study dealing with nanodrug delivery, nanofluid flow in a microchannel with various angles of drug injection is considered. The nanofluid is a solid-liquid mixture in which nonmetallic nanoparticles are suspended. A transient 3-D problem of controlled nanodrug delivery has been numerically solved. The velocity profile and dimensionless nanodrug concentration profile for different angles of drug injection were obtained at different axial stations along the length of the microchannel (z = 0.5, 5, and 10mm), with one particle diameter (10 nm) and one Reynolds number ratio (? = 1.69).