Abstract
AbstractDroplet microfluidic was devoted to design and fabricate robust devices in the field of biosensing, tissue engineering, drug delivery, cell encapsulation, cell isolation, and lab-on-a-chip. Chitosan was widely used for different biomedical applications because of its unique characteristics such as antibacterial bioactivities, immune-enhancing influences, and anticancer bioactivities. In this research, a model is used for investigating the formation and size of composite droplets in a microfluidic device. The role of the velocity flow ratio in the composite droplet characteristics such as the generation rate and composite droplet size is described. According to the results, a desirable protocol is developed to control the properties of the composite droplets and to compare the size and rate of the composite droplets in a micro device. Furthermore, the level set laminar two-phase flow approach is exploited for studying the composite droplet-breaking procedure. An experimental procedure is used for validation of the simulation process. Various sizes and geometries of the composite droplets are fabricated to depict a potential in biomedical applications such as bioimaging, biosensing, tissue engineering, drug delivery, cell encapsulation, cancer cell isolation, and lab-on-a-chip.
Highlights
Several methods have been developed for the synthesis of CS micro/nanoparticles such as ionic gelation, emulsification, coacervation, reverse micellar, and spray drying; they have a critical drawback of heterogeneous particles size distribution [37]
Microfluidic-assisted techniques allow the generation of monodisperse, multicomponent, and multi-functional drug micro/nanocarriers with favourably controllable chemical, physical, and biological characteristics to enhance the efficiency of cargo transport, release, distribution, and elimination in the treatment progress [58]
We described the role of physical properties of two immiscible liquids and flow rate ratios on the composite droplet geometries including size, shape, volume, length, formation, and velocity of droplets
Summary
Nanoparticles/nanomaterials have fascinated abundant curiosity in various fields of engineering and technology [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. Microfluidic-assisted techniques allow the generation of monodisperse, multicomponent, and multi-functional drug micro/nanocarriers with favourably controllable chemical, physical, and biological characteristics to enhance the efficiency of cargo transport, release, distribution, and elimination in the treatment progress [58] These systems are effectual for designing and fabricating drug micro/nanocarriers possessed programmed, ondemand, and tuneable release profile. Incorporating the microfluidic techniques and micro-engineered chip into a suitable device for controlled drug release applications in a chip or fabricating the drug micro/nanocarriers with promising organ-on-a-chip platforms permits cost-efficient investigations on the effectiveness of different drug delivery systems These promising microengineered systems can probably accomplish the break between the in vitro and in vivo studies [55]. We described the role of physical properties of two immiscible liquids and flow rate ratios on the composite droplet geometries including size, shape, volume, length, formation, and velocity of droplets
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