Abstract
Rapid pathogen sensing remains a pressing issue today since conventional identification methodsare tedious, cost intensive and time consuming, typically requiring from 48 to 72 h. In turn, chip based technologies, such as microarrays and microfluidic biochips, offer real alternatives capable of filling this technological gap. In particular microfluidic biochips make the development of fast, sensitive and portable diagnostic tools possible, thus promising rapid and accurate detection of a variety of pathogens. This paper will provide a broad overview of the novel achievements in the field of pathogen sensing by focusing on methods and devices that compliment microfluidics.
Highlights
The rapid detection and identification of microorganisms is a pressing issue in fields ranging from clinical diagnostics and monitoring of food-borne pathogens to detection of biological warfare agents.It is well known that health care systems would greatly benefit from faster, more accurate diagnosis to significantly reduce health care costs, while simultaneously providing better epidemiological data that can be used for infectious disease modeling [1]
Having reviewed the various materials and detection methods employed in lab-on-a-chip devices, we provide a detail list of LOC studies grouped by class of target analytes
In this review we discuss the latest advances, commercial applications and future trends of pathogen sensing methods combined with microfluidic systems
Summary
The rapid detection and identification of microorganisms is a pressing issue in fields ranging from clinical diagnostics and monitoring of food-borne pathogens to detection of biological warfare agents. Alternative detection methods for pathogen sensing include the application of silver dots for direct optical density measurements using a scanometric reader [45,46], or biosensors using resonance light scattering (RLS) techniques based on nanometer-sized metallic particles (mostly gold) covalently linked to antibodies. These metal colloidal particles radiate energy in the form of scattered light when illuminated by a white light source [47]. Having reviewed the various materials and detection methods employed in lab-on-a-chip devices, we provide a detail list of LOC studies grouped by class of target analytes
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