Abstract
Free liquid jets are a common sample delivery method in serial femtosecond x-ray (SFX) crystallography. Gas dynamic virtual nozzles (GDVNs) use an outer gas stream to focus a liquid jet down to a few micrometers in diameter. Such nozzles can be fabricated through various methods (capillary grinding, soft lithography, digital light processing, and two-photon polymerization) and materials, such as glass, polydimethylsiloxane, and photosensitive polyacrylates. Here, we present a broadly accessible, rapid prototyping laser ablation approach to micromachine solvent-resistant and inert Kapton polyimide foils with highly reproducible geometric features that result in 3D flow-focused GDVNs suitable for crystallography experiments at synchrotrons and free-electron laser facilities.
Highlights
Liquid jets are freely flowing liquid columns that achieve reliable sample delivery with minimal scattering background and a high signal-to-noise ratio
We previously reported on the use of pulsed laser ablation for the fabrication of microfluidic devices with 3D flowfocusing features.[19]
A robust Gas dynamic virtual nozzles (GDVNs) liquid jet system was created from thin Kapton foils by using a highly reproducible UV laser ablation procedure from multiple angles
Summary
Liquid jets are freely flowing liquid columns that achieve reliable sample delivery with minimal scattering background and a high signal-to-noise ratio. We present a broadly accessible, rapid prototyping laser ablation approach to micromachine solvent-resistant and inert Kapton polyimide foils with highly reproducible geometric features that result in 3D flow-focused GDVNs suitable for crystallography experiments at synchrotrons and free-electron laser facilities.
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