Abstract
This paper describes a dynamic microarray device that facilitates a particle-based multiplex analysis by co-locating multiple, hetero particles at a designated reaction chamber array. The device allows parallel monitoring of multiple reactions among clustered particles. A high-density particle cluster array was formed by utilizing flow-induced deformability of a polydimethylsiloxane (PDMS) membrane that is caused by applied hydrodynamic pressure. By incorporating immiscible oil isolation, particles clusters were isolated from the outer environment, which enabled a cross-contamination-free analysis. We monitored the interactions among clustered hetero particles, without any cross-contamination, by co-locating polystyrene beads and chemical-laden hydrogels within arrayed reaction chambers and isolating them using immiscible oil.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
