Abstract
Microfluidic systems have emerged as an important technology for modeling cellular microenvironments in vitro. These systems enable unprecedented levels of control of chemical gradients, fluid flow, and localized 3-D extracellular matrices (ECM), all of which can be integrated to provide a physiologically relevant context for studying complex cellular processes such as angiogenesis. Here, we describe the design and use of microfluidic systems for reproducing the dynamic events of vascular morphogenesis.
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