Microfluidic fabrication of microparticles with multiple structures from a biodegradable polymer blend

Abstract

We demonstrate control over the morphology and shape of microparticles. Two different types of microparticles (core–shell or acorn shaped) were produced by the varying the blend ratio of two immiscible biodegradable polymers in a tube-type microfluidic device. Subsequent use of selective solvent extraction resulted in the formation of hollow-core, crescent-shaped and dimple surfaced microparticles. A selective solvent, tetraglycol, which has been applied for intravenous injection in the human body, is used instead of organic solvents which can be toxic if remaining in microparticles.