Abstract
Sperm DNA Fragmentation is correlated with poor embryo development, implantation, euploidy and ongoing pregnancy rates. The current standard sperm processing method, density gradient selection (DGS), does not lower the DNA fragmentation Index (DFI) due to the centrifugation steps leading to creation of reactive oxygen species. It has been reported that microfluidic based sperm separation devices (MFSS) provide an alternative to centrifugation, selecting for the most motile and morphologically normal sperm with a decreased DFI and potentially improving euploidy and implantation rate in PGT-A cycles.
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