Abstract
Droplets produced within microfluidics have not only attracted the attention of researchers to develop complex biological, industrial and clinical testing systems but also played a role as a bit of data. The flow of droplets within a network of microfluidic channels by stimulation of their movements, trajectories, and interaction timing, can provide an opportunity for preparation of complex and logical microfluidic circuits. Such mechanical-based circuits open up avenues to mimic the logic of electrical circuits within microfluidics. Recently, simple microfluidic-based logical elements such as AND, OR, and NOT gates have been experimentally developed and tested to model basic logic conditions in laboratory settings. In this work, we develop new microfluidic networks, control the shape of channels and speed of droplet movement, and regulate the size of bubbles in order to extend the logical elements to six new logic gates, including AND/OR type 1, AND/OR type 2, NOT type 1, NOT type 2, Flip-Flop, Synchronizer, and a parametric model of T-junction as a bubble generator. We further designed and simulated a novel microfluidic Decoder 1 to 2, a Decoder 2 to 4, and a microfluidic circuit that combines several individual logic gates into one complex circuit. Further fabrication and experimental testing of these newly introduced logic gates within microfluidics enable implementing complex circuits in high-throughput microfluidic platforms for tissue engineering, drug testing and development, and chemical synthesis and process design.
Highlights
Droplets produced within microfluidics have attracted the attention of researchers to develop complex biological, industrial and clinical testing systems and played a role as a bit of data
The advances in droplet microfluidic platforms that are based on two-phase flow systems and denomination of bubble logics have enabled on-chip microfluidic data s treaming[2,3]
A reliable method to predict the behavior of fluidic logic gates is the analysis of two-phase flow systems which helps to execute universal Boolean operators and provides the opportunity to design droplet-level mechanisms in microfluidic o perators[12]
Summary
Droplets produced within microfluidics have attracted the attention of researchers to develop complex biological, industrial and clinical testing systems and played a role as a bit of data. For NOT gate type 1 microfluidic circuit, the geometry of the microchannel network contains two T-junctions for bubble generation (channel height: 100 μm) (Fig. 5a).
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