Abstract
The early detection of diseases is important to optimize clinical treatment. To meet the increasing requirement of rapid medical diagnosis, point-of-care testing (POCT) has drawn scientists’ great attention for its outstanding advantages including simple, efficient, inexpensive and instrument-independent. Recent advantages of microfluidic-based diagnosis have played an important role in the significant technological process of POCT, which can achieve rapid diagnosis and provide high precision testing results for correct clinical decision making. This review focuses on design strategies, detection targets and sensing mechanisms of recent microfluidic-based POCT for disease diagnosis. Further, we provide a perspective of the next generation of POCT devices and their future opportunities.
Highlights
Detection of disease is necessary for it may result in optimized treatment and reducing mortality
We focus on the microfabrication techniques, disease biomarkers and the detection strategies to demonstrate the design of microfluidic point-of-care testing (POCT) systems as well as their future perspectives, which will contribute to the development of nextgeneration POCT system
Various microfabrication technologies have been developed to achieve the development of microfluidic devices, which can be fabricated by various materials including glass and silicon, polymers, and paper
Summary
Detection of disease is necessary for it may result in optimized treatment and reducing mortality. [1,2,3,4] The diagnosis results can be quickly obtained using POCT system, which enables a more effective disease therapy and a correct use of drug. There is a significant technological progress in microfabrication technologies, which has already become an essential research area for microfluidic applications in pharmaceutics, environment and biomedical engineering research area. We focus on the microfabrication techniques, disease biomarkers and the detection strategies to demonstrate the design of microfluidic POCT systems as well as their future perspectives, which will contribute to the development of nextgeneration POCT system
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