Abstract
The present study is aimed to prepare the chitosan-coated alginate microspheres by an internal gelation technique with rutin as model drug. Recovery of microspheres and microspheres morphology were evaluated by determination of rutin encapsulation efficiency and microscope observation, respectively. The interaction between chitosan and alginate was assessed by differential scanning calorimetry (DSC). The microscope observation showed that the microspheres were homogeneous and the surface was spherical and smooth. The result of DSC indicated that the main force of complex formation was electrostatic interactions between ammonium of chitosan and carboxylate groups of alginate. In vitro release of the chitosan-coated alginate gel beads indicated that it had a satisfactory sustained releasing behavior for the drug within 20 h, and still maintain existed within 180 h. The microspheres which were biodegradable, biocompatible, metal ion adsorbable and persistable in environment may be applied to wastewater treatment.
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