Abstract
The objective of this study is to evaluate the solubility of an enteric polymer, Eudragit L100, in a supercritical CO2-ethanol mixture, and to produce spherical microcapsules for phenylalanine using Eudragit L100 as the coating substance by the PGSS process both at temperature 50 °C and pressures from 8 to 12 MPa. The average particle size obtained from the particles from gas saturated solution (PGSS) process decreased from 200.9 μm ± 20.5 μm to 140.6 μm ± 40.1 μm with increasing pressure from 8 to 12 MPa. The highest encapsulation efficiency of 68 ± 7% was obtained from the microcapsules produced from PGSS conducted at 50 ℃ and 10 MPa which SEM observation confirmed spherical microcapsules without aggregation. Sustained drug release assay of the microcapsules showed a sustained and enhanced drug release at low and high pH conditions, respectively, indicating successful micro coating of phenylalanine by Eudragit L100.
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