Microdoses de metformina aumentam as reservas de glicogenio em musculo esqueletico de ratos

Abstract

Recently, studies in diabetic rats and humans have shown that metformin treatment promotes a reduction of glycaemia by enhancing glucose uptake even in the absence of insulin. There is evidence of a relationship between metformin, hexoquinase activity, glucose uptake, and glycogen synthesis. The purpose of this study was to evaluate the muscle glycogen reserves of rats treated with microdoses of metformin for 15 days (1.6 µg.ml -1 or 3.2µg.ml -1 ). Our study showed that a 1.6 µg.ml -1 dose of metformin does not have an effect on glycogen synthesis, but a 3.2 µg.ml -1 of metformin increases the muscle glycogen reserves by 78% (p<0.05). We did not observe a hypoglycemic or a hiperlactemic effect. We concluded that a micro dose of metformin (3.2µg.ml -1 ) increases glycogen content and could