Abstract
The first full-length meeting on membrane rafts and caveo-lae, organized by Klaus Fiedler and Gerrit van Meer and spon-sored by EURESCO, washeld in the spectacularly situatedEden Roc hotel in San Feliu de Guixols, Spain, overlookingthe rugged Costa Brava coastline. Rafts and caveolae remainuncertain bedfellows. Although rafts (lipid microdomains de-fined by tight acyl chain packing) have a high affinity for cav-eolae (plasma membrane pits formed by caveolin proteins),the two are distinguishable; rafts can exist and function out-side of caveolae. Similarly, it is not yet clear how rafts areinvolved in caveolar function. At least some functions of cav-eolae appear to be mediated by binding of caveolins to otherproteins, with no obvious requirement for the unique raft lipidenvironment. We will focus here on the following themes,which were especially prominent at the meeting: raft struc-ture, the function of rafts and caveolae in transport along theexocytic and endocytic pathways, the role of rafts in sig-naling, and the function and dynamics of caveolin proteins.
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